Neutrophils not only play a critical role in host defense by migrating to the site of infection and producing reactive oxygen species (ROS), but also mediate pathological processes involved in tissue destruction. Therefore, it is important to assess and modulate neutrophil activities. Exhaustive exercise facilitates neutrophil activity, suggesting their involvement with muscle damage [1-4]. However, at that time, we needed to separate neutrophils from whole blood, and great care was needed to do this. Also, it took at least 1 h to adjust a fixed cell concentration of neutrophils for the functional analyses, and some researchers criticized the method, saying that the recovery rate was low and the neutrophil functions were altered from the in vivo environments. Because we observed complex phenomena centered on neutrophils following exercise, some novel technology was required to examine the neutrophil dynamics and functional modulation. Thus, I would like to share some of our research on neutrophils in relation with exercise and muscle damage. I will begin with my early studies on neutrophil functional analyses and a newly developed measurement system [5-7]. Then, some key data about effects of exercise, antioxidant modulation, mechanisms of exercise-induced muscle damage, and possible preventive countermeasures such as functional foods targeting pathogenesis will be described [7-10].


Professor ,Cooperative Major in Advanced Health Sciences, Tokyo University of Agriculture and Technology and Waseda University (PhD course only: 2010-2013); Adjunct Professor, Institute of Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Australia (2013-2014); President, International Society of Exercise and Immunology (ISEI) (2015-2017); Guest Editor, “Exercise and Inflammation” of Antioxidants (2017-2018); and Guest Editor, “Anti-inflammatory and Antioxidant Effects of Dietary Supplementation and Lifestyle factors” of Antioxidants (2019).