Abstract:

This study aims to apply a current progress on the construction and sense of carbon paste sensors based on carbon nanotubes (CNTs)/ TiO2 nanocomposite for verapamil hydrochloride determination. The role affecting the behavior of ionophore, lipophilic anionic additive as well as plasticizer is discussed carefully. The developed sensors were abbreviated as β-CDCPE and VER-PTCPE. These sensors exhibited excellent Nernstian behavior with linear dynamic ranges of 6.2 × 10-7 – 1.0 × 10-2 and 7.4 × 10-7 – 1.0 × 10-2 mol L-1, detection limits 2.0 × 10-7 and 3.5 × 10-7 mol L-1 and quantification limits 6.6 × 10-7 and 1.1 × 10-6 mol L-1 for β-CDCPE and VER-PTCPE, respectively. The investigated sensors showed adequate selectivity toward the target ion against some inorganic cations, neutral species and Diltiazem hydrochloride (drug with similar structure). The proposed potentiometric sensors were successfully performed for drug determination in pharmaceutical products, spiked surface water and human urine samples with good recovery data (98.46 and 99.06) for β-CDCPE and VER-PTCPE, respectively.

Biography:

I received my BSc, MSc and Ph. D degrees in Analytical Chemistry from Faculty of Science, Beni-Suef University, Egypt. My research is focused on ion-selective electrodes for drug determination and effect of nanomaterials on potentiometric sensors. I am preparing sensors for determination of inorganic compounds in variety real samples as a simple , sensitive, selective and low cost method.

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